A group of strangers, including a drunken doctor, a pregnant army officer's wife and an embezzling bank clerk, embarks on a dangerous journey across hostile territory. They are joined by an outlaw, falsely accused of murder, who helps them when a Sioux war party attacks. Remake of John Ford's Western, with Bing Crosby and Ann-Margret.

A group of unlikely travelling companions find themselves on the same stagecoach to Cheyenne. They include a drunken doctor, a bar girl who's been thrown out of town, a professional gambler, a travelling liquor salesman, a banker who has decided to embezzle money, a gun-slinger out for revenge and a young woman going to join her army captain husband. All have secrets but when they are set upon by an Indian war party and then a family of outlaws, they find they must all work together if they are to stay alive.