The FBI agent who first captured Hannibal Lecter is called out of retirement to catch a demented murderer dubbed the Tooth Fairy, who slaughters a family whenever there is a full moon - forcing the detective to draw on the imprisoned cannibal's expertise. Thriller prequel adapted from the first of Thomas Harris's Lecter novels, starring Anthony Hopkins, Edward Norton, Ralph Fiennes and Philip Seymour Hoffman.

Former FBI Agent Will Graham, who was once almost killed by the savage Hannibal 'The Cannibal' Lecter, now has no choice but to face him again, as it seems Lecter is the only one who can help Graham track down a new serial killer.