The teenage sleuth returns for a feature-length adventure as she enrolls in college. No sooner has she arrived than a drug overdose leaves the star football player in a coma. The finger of suspicion immediately points to the athlete's girlfriend, but Nancy suspects there is someone else behind this event and can't resist snooping around. However, her investigation gets her arrested and almost expelled. Family drama, starring Maggie Lawson and Jill Ritchie.

Nancy and her faithful sidekicks Bess and George just entered River Heights University, where she tackles the mystery of a football star's drug-induced coma.