A quadriplegic ex-cop is saved from the brink of suicide by a rookie female officer needing his expertise to form a psychological profile of a serial killer. The murderer is posing as a cab driver and terrorising Manhattan, and has a gruesome habit of taking trophies from his victims' bodies. Thriller, starring Denzel Washington, Angelina Jolie, Michael Rooker, Mike McGlone, Luis Guzman and Queen Latifah.

Lincoln Rhyme was the department's top homicide detective and leading expert in criminal forensics until an injury left him paralyzed, depressed, and incapable of working. But when a gruesome murder in Manhattan leaves detectives baffled, they call on Rhyme to help solve the mystery. Amelia Donaghy, a rookie cop whose quick thinking preserved a gruesome murder scene, is enlisted by Rhyme to be his on-the-scene forensics expert. With Amelia reluctantly acting as Rhyme's able-bodied go-between, the pair piece together cryptic clues the killer leaves behind at the scene of the crime, hoping to catch the grisly serial killer.