The half-vampire swordsman teams up with his lifelong foes to defeat a horde of mutant bloodsuckers who lack many of the usual weaknesses and are preying on human and vampire alike. Guillermo del Toro's action thriller sequel, starring Wesley Snipes, Kris Kristofferson, Leonor Varela, Norman Reedus and Luke Goss.

Blade forms an uneasy alliance with the vampire council in order to combat the Reapers, who are feeding on vampires.