Fact-based drama, chronicling the travels of a young Che Guevara. In 1952, the future revolutionary is a medical student who plans to serve his residency in a leper colony. Seeking a little excitement along the way, he and a friend decide to travel to the colony by motorbike, a journey that will take them across South America. However, both men are changed forever by the things they see along the way. Starring Gael Garcia Bernal, Rodrigo de la Serna, Mia Maestro and Gustavo Bueno. In Spanish, Quechua and Mapudungun.

Based on the journals of Che Guevara, leader of the Cuban Revolution. In his memoirs, Guevara recounts adventures he and best friend Alberto Granado had while crossing South America by motorcycle in the early 1950s.