In the future, the world has been devastated by a war between humans and vampires. An enclave of human survivors lives under the domination of a religious hierarchy. A war veteran-turned-priest breaks his oath to the church and sets off in search of his niece, who has been kidnapped by vampires. Fantasy action thriller, with Paul Bettany, Karl Urban and Maggie Q.

In an alternate world, humanity and vampires have warred for centuries. After the last Vampire War, the veteran Warrior Priest lives in obscurity with other humans inside one of the Church's walled cities. When the Priest's niece is kidnapped by vampires, the Priest breaks his vows to hunt them down. He is accompanied by the niece's boyfriend, who is a wasteland sheriff, and a former Warrior Priestess.