An intergalactic mission starts to go horribly wrong in this dull and often incomprehensible sci-fi shocker from director Christian Alvart (Antibodies, Case 39). When astronauts Dennis Quaid and Ben Foster awake disorientated from hyper-sleep, with no memory of their assignment, they find themselves at the mercy of fast-moving mutant monsters that have infiltrated their ship. That's if the eponymous deep-space disease (or Orbital Dysfunctional Syndrome) that manifests itself as a delusional God complex doesn't get to them first. Pitch Black, Alien and producer Paul WS Anderson's own Event Horizon and Resident Evil franchise are obvious reference points in this hopelessly muddled mix. But it's essentially The Descent in outer space with no real menace or horror, just jerky editing supplying mechanical jolts against a dingy industrial backdrop.

Two crew members wake up on an abandoned spacecraft with no idea who they are, how long they've been asleep, or what their mission is. The two soon discover they're actually not alone – and the reality of their situation is more horrifying than they could have imagined.