A scientist believes he has saved the world from his invention, a machine that accidentally turned water into food. However, he learns the device is still active and has created a race of food/animal hybrids that he must stop from running wild across the world. Animated comedy sequel, with the voices of Bill Hader, Anna Faris and James Caan.

After the disastrous food storm in the first film, Flint and his friends are forced to leave the town. Flint accepts the invitation from his idol Chester V to join The Live Corp Company, which has been tasked to clean the island, and where the best inventors in the world create technologies for the betterment of mankind. When Flint discovers that his machine still operates and now creates mutant food beasts like living pickles, hungry tacodiles, shrimpanzees and apple pie-thons, he and his friends must return to save the world.