The fragile truce between warring canines and felines crumbles when a scientist begins working on a cure for all humans who are allergic to dogs. A power-mad Persian cat plots to sabotage the invention in his battle for world domination, but a heroic puppy joins a force of canine secret agents to foil his schemes. Comedy, starring Jeff Goldblum and Elizabeth Perkins, and featuring the voices of Tobey Maguire, Alec Baldwin, Susan Sarandon and Sean Hayes.