Ex-convict Elwood Blues sets about re-forming his band to raise funds for a children's hospital. But no sooner has he found a suitable lead singer to replace his late brother Jake, than the band end up being pursued by the police, the Russian mafia and his own embittered stepbrother. Comedy sequel, starring Dan Aykroyd, John Goodman and Joe Morton.

Finally released from prison, Elwood Blues is once again enlisted by Sister Mary Stigmata in her latest crusade to raise funds for a children's hospital. Hitting the road to re-unite the band and win the big prize at the New Orleans Battle of the Bands, Elwood is pursued cross-country by the cops.