The fearless warrior's blood-sucking foes frame him for murder, forcing him to go on the run from the FBI while his enemies resurrect the first and most powerful of their kind - Dracula himself. Joining forces with a team of human vampire slayers, Blade embarks on a quest to wipe out the undead menace once and for all. Action thriller sequel, with Wesley Snipes, Jessica Biel, Ryan Reynolds, Parker Posey, Kris Kristofferson and Dominic Purcell.

For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.