Infamous mad scientist Herbert West is locked up within a maximum-security prison. The unhinged doctor continues his dubious experiments with the help of a naive prison medic, hatching a plan to extract souls from his victims and transplant them into reanimated corpses. Horror sequel, starring Jeffrey Combs and Jason Barry.

Once again tampering with mother nature to disastrous results, Dr. Herbert West continues his research while serving time in a maximum security prison for his previous exploits. West's limited prison-cell experiments are suddenly interrupted by the arrival of a new prison doctor and the brother of the girl who suffered from West's experiments 13 years earlier.