A mild-mannered doctor sets up practice in a small town, but a cloud gathers over his career due to a series of unexplained deaths. Before long, he has to convince the locals that a horde of venomous spiders is responsible and confront his intense fear of arachnids into the bargain. Comedy horror, starring Jeff Daniels, John Goodman, Julian Sands and Brian McNamara.

A large spider from the jungles of South America is accidentally transported in a crate with a dead body to America where it mates with a local spider. Soon after, the residents of a small California town disappear as the result of spider bites from the deadly spider offspring. It's up to a couple of doctors with the help of an insect exterminator to annihilate these eight legged freaks.